Experimental Demyelination and Axonal Loss Are Reduced in MicroRNA-146a Deficient Mice

Experimental Demyelination and Axonal Loss Are Reduced in MicroRNA-146a Deficient Mice

BackgroundThe cuprizone (CPZ) model of multiple sclerosis (MS) was used to identify microRNAs (miRNAs) related to in vivo de- and remyelination. We further investigated the role of miR-146a in miR-146a-deficient (KO) mice: this miRNA is differentially expressed in MS lesions and promotes differentia...

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Bibliographic Details
Main Authors: Nellie A. Martin, Viktor Molnar, Gabor T. Szilagyi, Maria L. Elkjaer, Arkadiusz Nawrocki, Justyna Okarmus, Agnieszka Wlodarczyk, Eva K. Thygesen, Miklos Palkovits, Ferenc Gallyas, Martin R. Larsen, Hans Lassmann, Eirikur Benedikz, Trevor Owens, Asa F. Svenningsen, Zsolt Illes
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Immunology
Subjects:
cuprizone
miR-146a
miR-181b
miR-193a
demyelination
remyelination
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00490/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00490/full

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