Mathematical modeling of oncogenesis control in mature T-cell populations

Mathematical modeling of oncogenesis control in mature T-cell populations

T-cell receptor (TCR) polyclonal mature T cells are surprisingly resistant to oncogenic transformation after retroviral insertion of T-cell oncogenes. In a mouse model, it has been shown that mature T-cell lymphoma / leukemia (MTCLL) is not induced upon transplantation of mature, TCR polyclonal wild...

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Bibliographic Details
Main Authors: Sebastian eGerdes, Sebastian eNewrzela, Ingmar eGlauche, Dorothee evon Laer, Martin-Leo eHansmann, Ingo eRoeder
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-11-01
Series:Frontiers in Immunology
Subjects:
Gene Therapy
T-cell homeostasis
T-cell niche
mature T-cell lymphoma
MTCL
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00380/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00380/full

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