Exosomes Derived from Hypoxia-Cultured Human Adipose Stem Cells Alleviate Articular Chondrocyte Inflammaging and Post-Traumatic Osteoarthritis Progression

Exosomes Derived from Hypoxia-Cultured Human Adipose Stem Cells Alleviate Articular Chondrocyte Inflammaging and Post-Traumatic Osteoarthritis Progression

Osteoarthritis (OA) is the most common age-related degenerative joint disease. Inflammaging, linking inflammation and aging, is found in senescent cells with the secretions of matrix-degrading proteins and proinflammatory cytokines. The senescence-associated secretory phenotype (SASP) plays a very i...

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Bibliographic Details
Main Authors: Ling-Hua Chang, Shun-Cheng Wu, Chung-Hwan Chen, Jhen-Wei Chen, Wan-Chun Huang, Che-Wei Wu, Yi-Shan Lin, Yu-Ju Chen, Je-Ken Chang, Mei-Ling Ho
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:International Journal of Molecular Sciences
Subjects:
exosomes
micro ribonucleic acid (miRNA)
articular chondrocytes
hypoxia
inflammaging
SASP (senescence-associated secretory phenotype)
Online Access:https://www.mdpi.com/1422-0067/24/17/13414

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https://www.mdpi.com/1422-0067/24/17/13414

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