Design and Synthesis of Non-Covalent Imidazo[1,2-<i>a</i>]quinoxaline-Based Inhibitors of EGFR and Their Anti-Cancer Assessment

Design and Synthesis of Non-Covalent Imidazo[1,2-<i>a</i>]quinoxaline-Based Inhibitors of EGFR and Their Anti-Cancer Assessment

A series of 30 non-covalent imidazo[1,2-<i>a</i>]quinoxaline-based inhibitors of epidermal growth factor receptor (EGFR) were designed and synthesized. EGFR inhibitory assessment (against wild type) data of compounds revealed <b>6b</b>, <b>7h</b>, <b>7j</...

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Bibliographic Details
Main Authors: Manvendra Kumar, Gaurav Joshi, Sahil Arora, Tashvinder Singh, Sajal Biswas, Nisha Sharma, Zahid Rafiq Bhat, Kulbhushan Tikoo, Sandeep Singh, Raj Kumar
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Molecules
Subjects:
imidazo[1,2-<i>a</i>]quinoxaline
non-covalent EGFR inhibitors
anticancer agents
mutant EGFR inhibitors
Online Access:https://www.mdpi.com/1420-3049/26/5/1490

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https://www.mdpi.com/1420-3049/26/5/1490

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