DNAJB1-PRKACA in HEK293T cells induces LINC00473 overexpression that depends on PKA signaling.

Fibrolamellar carcinoma (FLC) is a primary liver cancer that most commonly arises in adolescents and young adults in a background of normal liver tissue and has a poor prognosis due to lack of effective chemotherapeutic agents. The DNAJB1-PRKACA gene fusion (DP) has been reported in the majority of...

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Main Authors: Stephanie S Kim, Ina Kycia, Michael Karski, Rosanna K Ma, Evan A Bordt, Julian Kwan, Anju Karki, Elle Winter, Ranan G Aktas, Yuxuan Wu, Andrew Emili, Daniel E Bauer, Praveen Sethupathy, Khashayar Vakili
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0263829