Alcohol and HIV-Derived Hepatocyte Apoptotic Bodies Induce Hepatic Stellate Cell Activation

Alcohol and HIV-Derived Hepatocyte Apoptotic Bodies Induce Hepatic Stellate Cell Activation

Recently, we found that both HIV and acetaldehyde, an alcohol metabolite, induce hepatocyte apoptosis, resulting in the release of large extracellular vesicles called apoptotic bodies (ABs). The engulfment of these hepatocyte ABs by hepatic stellate cells (HSC) leads to their profibrotic activation....

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Bibliographic Details
Main Authors: Moses New-Aaron, Raghubendra Singh Dagur, Siva Sankar Koganti, Murali Ganesan, Weimin Wang, Edward Makarov, Mojisola Ogunnaike, Kusum K. Kharbanda, Larisa Y. Poluektova, Natalia A. Osna
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Biology
Subjects:
hepatocytes
apoptotic bodies
hepatic stellate cells
JNK-ERK1/2
reactive oxygen species
JAK-STAT3
Online Access:https://www.mdpi.com/2079-7737/11/7/1059

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https://www.mdpi.com/2079-7737/11/7/1059

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