Nef neutralizes the ability of exosomes from CD4+ T cells to act as decoys during HIV-1 infection.
Nef is an HIV-1 accessory protein that promotes viral replication and pathogenesis. A key function of Nef is to ensure sustained depletion of CD4 and MHC-I molecules in infected cells by inducing targeting of these proteins to multivesicular bodies (MVBs), and ultimately to lysosomes for degradation...
| Main Authors: | , , , , , , , , , |
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| 格式: | 文件 |
| 语言: | English |
| 出版: |
Public Library of Science (PLoS)
2014-01-01
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| 丛编: | PLoS ONE |
| 在线阅读: | https://doi.org/10.1371/journal.pone.0113691 |