Targeting BMI‐1 to deplete antibody‐secreting cells in autoimmunity

Targeting BMI‐1 to deplete antibody‐secreting cells in autoimmunity

Abstract Objectives B cells drive the production of autoreactive antibody‐secreting cells (ASCs) in autoimmune diseases such as Systemic Lupus Erythematosus (SLE) and Sjögren's syndrome, causing long‐term organ damage. Current treatments for antibody‐mediated autoimmune diseases target B cells...

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Bibliographic Details
Main Authors: Jack Polmear, Lauren Hailes, Moshe Olshansky, Maureen Rischmueller, Elan L'Estrange‐Stranieri, Anne L Fletcher, Margaret L Hibbs, Vanessa L Bryant, Kim L Good‐Jacobson
Format: Article
Language:English
Published: Wiley 2023-01-01
Series:Clinical & Translational Immunology
Subjects:
antibody
autoimmunity
B cells
BMI‐1
Sjögren's syndrome
Systemic Lupus Erythematosus
Online Access:https://doi.org/10.1002/cti2.1470

Internet

https://doi.org/10.1002/cti2.1470

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