ZNF827 is a single-stranded DNA binding protein that regulates the ATR-CHK1 DNA damage response pathway

ZNF827 is a single-stranded DNA binding protein that regulates the ATR-CHK1 DNA damage response pathway

Abstract The ATR-CHK1 DNA damage response pathway becomes activated by the exposure of RPA-coated single-stranded DNA (ssDNA) that forms as an intermediate during DNA damage and repair, and as a part of the replication stress response. Here, we identify ZNF827 as a component of the ATR-CHK1 kinase p...

Full description

Bibliographic Details
Main Authors: Sile F. Yang, Christopher B. Nelson, Jadon K. Wells, Madushan Fernando, Robert Lu, Joshua A. M. Allen, Lisa Malloy, Noa Lamm, Vincent J. Murphy, Joel P. Mackay, Andrew J. Deans, Anthony J. Cesare, Alexander P. Sobinoff, Hilda A. Pickett
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-46578-0

Internet

https://doi.org/10.1038/s41467-024-46578-0

Similar Items