A novel PSMA-targeting tracer with highly negatively charged linker demonstrates decreased salivary gland uptake in mice compared to [68Ga]Ga-PSMA-11

A novel PSMA-targeting tracer with highly negatively charged linker demonstrates decreased salivary gland uptake in mice compared to [68Ga]Ga-PSMA-11

Abstract Background The current generation of radiolabeled PSMA-targeting therapeutic agents is limited by prominent salivary gland binding, which results in dose-limiting xerostomia from radiation exposure. JB-1498 is a urea-based small molecule with a highly negatively charged linker targeting pro...

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Bibliographic Details
Main Authors: Steve S. Huang, Frank P. DiFilippo, Daniel J. Lindner, Warren D. Heston
Format: Article
Language:English
Published: SpringerOpen 2024-01-01
Series:EJNMMI Radiopharmacy and Chemistry
Subjects:
PSMA
GCP-II
Prostate cancer
Salivary gland toxicity
Online Access:https://doi.org/10.1186/s41181-024-00237-3

Internet

https://doi.org/10.1186/s41181-024-00237-3

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