Detecting Selection in the HIV-1 Genome during Sexual Transmission Events

Detecting Selection in the HIV-1 Genome during Sexual Transmission Events

Little is known about whether and how variation in the HIV-1 genome affects its transmissibility. Assessing which genomic features of HIV-1 are under positive or negative selection during transmission is challenging, because very few virus particles are typically transmitted, and random genetic drif...

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Bibliographic Details
Main Authors: David Seifert, Beda Joos, Dominique L. Braun, Corinna S. Oberle, Corinne D. Schenkel, Herbert Kuster, Christina Grube, Jürg Böni, Sabine Yerly, Vincent Aubert, Thomas Klimkait, Huldrych F. Günthard, Niko Beerenwinkel, Karin J. Metzner, on behalf of the Swiss HIV Cohort Study
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Viruses
Subjects:
HIV-1
transmission
transmitter–recipient pairs
Selection Test in Transmission (SeTesT)
Vpu
ZPHI
Online Access:https://www.mdpi.com/1999-4915/14/2/406

Internet

https://www.mdpi.com/1999-4915/14/2/406

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