Role of ADAM10 and ADAM17 in Regulating CD137 Function

Role of ADAM10 and ADAM17 in Regulating CD137 Function

Human CD137 (4-1BB), a member of the TNF receptor family, and its ligand CD137L (4-1BBL), are expressed on immune cells and tumor cells. CD137/CD137L interaction mediates bidirectional cellular responses of potential relevance in inflammatory diseases, autoimmunity and oncology. A soluble form of CD...

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Bibliographic Details
Main Authors: Jana Seidel, Sinje Leitzke, Björn Ahrens, Maria Sperrhacke, Sucharit Bhakdi, Karina Reiss
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
CD137
ADAM10
ADAM17
Anoctamin-6
T cell proliferation
cancer
Online Access:https://www.mdpi.com/1422-0067/22/5/2730

Internet

https://www.mdpi.com/1422-0067/22/5/2730

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