Detection of four rare thalassemia variants using Single-molecule realtime sequencing

Detection of four rare thalassemia variants using Single-molecule realtime sequencing

Conventional methods for the diagnosis of thalassemia include gap polymerase chain reaction (Gap-PCR), reverse membrane hybridization (RDB), multiplex ligation-dependent probe amplification (MLPA) and Sanger sequencing. In this study, we used single molecule real-time technology (SMRT) sequencing an...

Full description

Bibliographic Details
Main Authors: Shiqiang Luo, Xingyuan Chen, Dingyuan Zeng, Ning Tang, Dejian Yuan, Bailing Liu, Lizhu Chen, Qingyan Zhong, Jiaqi Li, Yinyin Liu, Jianping Chen, Xiaoyuan Wang, Tizhen Yan
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Genetics
Subjects:
single molecule real-time technology
carrier screening
αthalassemia
ß-thalassemia
rarevariant
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2022.974999/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2022.974999/full

Similar Items