Long term high glucose exposure induces premature senescence in retinal endothelial cells

Long term high glucose exposure induces premature senescence in retinal endothelial cells

Purpose: Features of cellular senescence have been described in diabetic retinal vasculature. The aim of this study was to investigate how the high glucose microenvironment impacts on the senescence program of retinal endothelial cells.Methods: Human retinal microvascular endothelial cells were cult...

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Bibliographic Details
Main Authors: Pietro Maria Bertelli, Edoardo Pedrini, David Hughes, Shannon McDonnell, Varun Pathak, Elisa Peixoto, Jasenka Guduric-Fuchs, Alan W Stitt, Reinhold J. Medina
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Physiology
Subjects:
diabetic retina
senescence
retinal microvasculature
diabetic retina complications
vascular biology
senescence-associated secretory phenotype
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2022.929118/full

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https://www.frontiersin.org/articles/10.3389/fphys.2022.929118/full

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