Oral metformin transiently lowers post-prandial glucose response by reducing the apical expression of sodium-glucose co-transporter 1 in enterocytes

Oral metformin transiently lowers post-prandial glucose response by reducing the apical expression of sodium-glucose co-transporter 1 in enterocytes

Summary: Metformin (MET) is the most prescribed antidiabetic drug, but its mechanisms of action remain elusive. Recent data point to the gut as MET’s primary target. Here, we explored the effect of MET on the gut glucose transport machinery. Using human enterocytes (Caco-2/TC7 cells) in vitro, we sh...

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Bibliographic Details
Main Authors: Lorea Zubiaga, Olivier Briand, Florent Auger, Veronique Touche, Thomas Hubert, Julien Thevenet, Camille Marciniak, Audrey Quenon, Caroline Bonner, Simon Peschard, Violeta Raverdy, Mehdi Daoudi, Julie Kerr-Conte, Gianni Pasquetti, Hermann Koepsell, Daniela Zdzieblo, Markus Mühlemann, Bernard Thorens, Nathalie D. Delzenne, Laure B. Bindels, Benoit Deprez, Marie C. Vantyghem, Blandine Laferrère, Bart Staels, Damien Huglo, Sophie Lestavel, François Pattou
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:iScience
Subjects:
Drugs
Molecular physiology
Endocrinology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223001347

Internet

http://www.sciencedirect.com/science/article/pii/S2589004223001347

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