Activated Protein C Inhibits Proliferation and Tumor Necrosis Factor α-Stimulated Activation of p38, c-Jun NH2-Terminal Kinase (JNK) and Akt in Rheumatoid Synovial Fibroblasts

Activated Protein C Inhibits Proliferation and Tumor Necrosis Factor α-Stimulated Activation of p38, c-Jun NH2-Terminal Kinase (JNK) and Akt in Rheumatoid Synovial Fibroblasts

Abstract Synovial fibroblast proliferation Is a hallmark of the Invasive pannus in the rheumatoid joint. Activated protein C (APC) is a natural anticoagulant that exerts antiinflammatory and cyto-protective effects in various diseases via endothelial protein C receptor (EPCR) and proteinase-activate...

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Bibliographic Details
Main Authors: Sohel M. Julovi, Kaitlin Shen, Kelly McKelvey, Nikita Minhas, Lyn March, Christopher J. Jackson
Format: Article
Language:English
Published: BMC 2013-09-01
Series:Molecular Medicine
Subjects:
Rheumatoid Synovial Fibroblasts (RSFs)
Human RSFs
Endothelial Protein C Receptor (EPCR)
Normal HDFs
Mouse Dermal Fibroblasts (MDFs)
Online Access:https://doi.org/10.2119/molmed.2013.00034

Internet

https://doi.org/10.2119/molmed.2013.00034

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