Automatic Optimization of an in Silico Model of Human iPSC Derived Cardiomyocytes Recapitulating Calcium Handling Abnormalities

Automatic Optimization of an in Silico Model of Human iPSC Derived Cardiomyocytes Recapitulating Calcium Handling Abnormalities

The growing importance of human induced pluripotent stem cell-derived cardiomyoyctes (hiPSC-CMs), as patient-specific and disease-specific models for studying cellular cardiac electrophysiology or for preliminary cardiotoxicity tests, generated better understanding of hiPSC-CM biophysical mechanisms...

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Bibliographic Details
Main Authors: Michelangelo Paci, Risto-Pekka Pölönen, Dario Cori, Kirsi Penttinen, Katriina Aalto-Setälä, Stefano Severi, Jari Hyttinen
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Physiology
Subjects:
human induced pluripotent stem cell-derived cardiomyocyte
action potential
calcium transient
computer simulation
in silico modeling
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.00709/full

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https://www.frontiersin.org/article/10.3389/fphys.2018.00709/full

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