Automatic Optimization of an in Silico Model of Human iPSC Derived Cardiomyocytes Recapitulating Calcium Handling Abnormalities

The growing importance of human induced pluripotent stem cell-derived cardiomyoyctes (hiPSC-CMs), as patient-specific and disease-specific models for studying cellular cardiac electrophysiology or for preliminary cardiotoxicity tests, generated better understanding of hiPSC-CM biophysical mechanisms...

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Bibliografische gegevens
Hoofdauteurs: Michelangelo Paci, Risto-Pekka Pölönen, Dario Cori, Kirsi Penttinen, Katriina Aalto-Setälä, Stefano Severi, Jari Hyttinen
Formaat: Artikel
Taal:English
Gepubliceerd in: Frontiers Media S.A. 2018-06-01
Reeks:Frontiers in Physiology
Onderwerpen:
Online toegang:https://www.frontiersin.org/article/10.3389/fphys.2018.00709/full