Thymoquinone protects the testes of hypothyroid rats by suppressing pro-inflammatory cytokines and oxidative stress and promoting SIRT1 testicular expression

Thymoquinone protects the testes of hypothyroid rats by suppressing pro-inflammatory cytokines and oxidative stress and promoting SIRT1 testicular expression

Background: Hypothyroidism has been linked to many testicular structural and dysfunctional changes in males. Thymoquinone (TQ) has shown a potent testicular protective effect through its antioxidant, anti-inflammatory, antiapoptotic, fertility-enhancing, and endocrine modulatory activities.Objective...

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Bibliographic Details
Main Authors: Sami A. Algaidi, Khadija A. Faddladdeen, Ghadeer I. Alrefaei, Safa H. Qahl, Emad A. Albadawi, Hailah M. ALmohaimeed, Nasra N. Ayuob
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Pharmacology
Subjects:
thymoquinone
testis
hypothyroidism
rat
SIRT1
TNF-α
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.1040857/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.1040857/full

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