PP2A‐based triple‐strike therapy overcomes mitochondrial apoptosis resistance in brain cancer cells

PP2A‐based triple‐strike therapy overcomes mitochondrial apoptosis resistance in brain cancer cells

Mitochondrial glycolysis and hyperactivity of the phosphatidylinositol 3‐kinase–protein kinase B (AKT) pathway are hallmarks of malignant brain tumors. However, kinase inhibitors targeting AKT (AKTi) or the glycolysis master regulator pyruvate dehydrogenase kinase (PDKi) have failed to provide clini...

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Bibliographic Details
Main Authors: Oxana V. Denisova, Joni Merisaari, Riikka Huhtaniemi, Xi Qiao, Laxman Yetukuri, Mikael Jumppanen, Amanpreet Kaur, Mirva Pääkkönen, Сarina vonSchantz‐Fant, Michael Ohlmeyer, Krister Wennerberg, Otto Kauko, Raphael Koch, Tero Aittokallio, Mikko Taipale, Jukka Westermarck
Format: Article
Language:English
Published: Wiley 2023-09-01
Series:Molecular Oncology
Subjects:
AKT
apoptosis
glioblastoma
mitochondria
PDK
PP2A
Online Access:https://doi.org/10.1002/1878-0261.13488

Internet

https://doi.org/10.1002/1878-0261.13488

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