Flubendazole inhibits PD-1 and suppresses melanoma growth in immunocompetent mice

Flubendazole inhibits PD-1 and suppresses melanoma growth in immunocompetent mice

Abstract Background Immune checkpoint inhibitor therapy has revolutionized the clinical management of a diverse range of cancer types, including advanced cutaneous melanoma. While immunotherapy targeting the PD-1/PD-L1 system has become standard of care, overall response rates remain unsatisfactory...

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Bibliographic Details
Main Authors: Yue Li, Ben Wu, Md Jakir Hossain, Lily Quagliata, Connor O’Meara, Marc R. Wilkins, Susan Corley, Levon M. Khachigian
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Journal of Translational Medicine
Subjects:
Flubendazole
Benzimidazole
Melanoma
Programmed cell death protein-1
Online Access:https://doi.org/10.1186/s12967-023-04289-y

Internet

https://doi.org/10.1186/s12967-023-04289-y

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