GRIN2B-related neurodevelopmental disorder: current understanding of pathophysiological mechanisms

GRIN2B-related neurodevelopmental disorder: current understanding of pathophysiological mechanisms

The GRIN2B-related neurodevelopmental disorder is a rare disease caused by mutations in the GRIN2B gene, which encodes the GluN2B subunit of NMDA receptors. Most individuals with GRIN2B-related neurodevelopmental disorder present with intellectual disability and developmental delay. Motor impairment...

Full description

Bibliographic Details
Main Authors: Shasta L. Sabo, Jessica M. Lahr, Madelyn Offer, Anika LA Weekes, Michael P. Sceniak
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Synaptic Neuroscience
Subjects:
GRIN2B
GluN2B (NMDA receptor subunit NR2B)
dendrite development
autism (ASD)
neuron development
disease variants
Online Access:https://www.frontiersin.org/articles/10.3389/fnsyn.2022.1090865/full

Internet

https://www.frontiersin.org/articles/10.3389/fnsyn.2022.1090865/full

Similar Items