Quasi-perfusion studies for intensified lentiviral vector production using a continuous stable producer cell line

Quasi-perfusion studies for intensified lentiviral vector production using a continuous stable producer cell line

Quasi-perfusion culture was employed to intensify lentiviral vector (LV) manufacturing using a continuous stable producer cell line in an 8-day process. Initial studies aimed to identify a scalable seeding density, with 3, 4, and 5 × 104 cells cm−2 providing similar specific productivities of infect...

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Bibliografiske detaljer
Main Authors: Dale J. Stibbs, Pedro Silva Couto, Yasuhiro Takeuchi, Qasim A. Rafiq, Nigel B. Jackson, Andrea C.M.E. Rayat
Format: Article
Sprog:English
Udgivet: Elsevier 2024-06-01
Serier:Molecular Therapy: Methods & Clinical Development
Fag:
lentiviral vector
process intensification
quasi-perfusion processing
scale-up
fixed-bed bioreactor
stable producer cell line
Online adgang:http://www.sciencedirect.com/science/article/pii/S2329050124000809

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http://www.sciencedirect.com/science/article/pii/S2329050124000809

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