Purine Synthesis Inhibitor L-Alanosine Impairs Mitochondrial Function and Stemness of Brain Tumor Initiating Cells

Purine Synthesis Inhibitor L-Alanosine Impairs Mitochondrial Function and Stemness of Brain Tumor Initiating Cells

Glioblastoma (GBM) is a lethal brain cancer exhibiting high levels of drug resistance, a feature partially imparted by tumor cell stemness. Recent work shows that homozygous <i>MTAP</i> deletion, a genetic alteration occurring in about half of all GBMs, promotes stemness in GBM cells. Ex...

Full description

Bibliographic Details
Main Authors: Simranjit X. Singh, Rui Yang, Kristen Roso, Landon J. Hansen, Changzheng Du, Lee H. Chen, Paula K. Greer, Christopher J. Pirozzi, Yiping He
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Biomedicines
Subjects:
alanosine
adenine
purine
MTAP
glioma stem cells
mitochondria
Online Access:https://www.mdpi.com/2227-9059/10/4/751

Internet

https://www.mdpi.com/2227-9059/10/4/751

Similar Items