Reduction in Migratory Phenotype in a Metastasized Breast Cancer Cell Line via Downregulation of S100A4 and GRM3

Abstract To investigate phenotypic and genotypic alterations before and after bone metastasis, we conducted genome-wide mRNA profiling and DNA exon sequencing of two cell lines (TMD and BMD) derived from a mouse xenograft model. TMD cells were harvested from the mammary fat pad after transfecting MD...

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Bibliographic Details
Main Authors: Andy Chen, Luqi Wang, Bai-Yan Li, Jesse Sherman, Jong E. Ryu, Kazunori Hamamura, Yunlong Liu, Harikrishna Nakshatri, Hiroki Yokota
Format: Article
Language:English
Published: Nature Portfolio 2017-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-03811-9