Construction of self-driving anti-αFR CAR-engineered NK cells based on IFN-γ and TNF-α synergistically induced high expression of CXCL10

Construction of self-driving anti-αFR CAR-engineered NK cells based on IFN-γ and TNF-α synergistically induced high expression of CXCL10

Introduction: Ovarian cancer is the most malignant gynecological tumor. Previous studies have demonstrated that chimeric antigen receptor (CAR)-engineered NK-92 cells targeting folate receptor α (αFR) (NK-92-αFR-CAR) can specifically kill αFR-positive ovarian cancer cells. However, the migration bar...

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Bibliographic Details
Main Authors: Min He, Xiang Ao, Yu Yang, Yanmin Xu, Tao Liu, Luoquan Ao, Wei Guo, Wei Xing, Jing Xu, Cheng Qian, Jianhua Yu, Xiang Xu, Ping Yi
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
CAR-NK
CXCL10
CXCR3
Immunotherapy
Ovarian cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558624001064

Internet

http://www.sciencedirect.com/science/article/pii/S1476558624001064

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