Ion channelopathies in human induced pluripotent stem cell derived cardiomyocytes: a dynamic clamp study with virtual IK1

Ion channelopathies in human induced pluripotent stem cell derived cardiomyocytes: a dynamic clamp study with virtual IK1

Human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) are widely used in studying basic mechanisms of cardiac arrhythmias that are caused by ion channelopathies. Unfortunately, the action potential profile of hiPSC-CMs—and consequently the profile of individual membrane currents act...

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Bibliographic Details
Main Authors: Rosalie M.E. Meijer van Putten, Isabella eMengarelli, Kaomei eGuan, Jan G. Zegers, Antoni CG van Ginneken, Arie O Verkerk, Ronald eWilders
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-02-01
Series:Frontiers in Physiology
Subjects:
Action Potentials
patch clamp
Andersen-Tawil syndrome
inward rectifier potassium channel
cardiac ion channelopathies
KCNJ2 gene
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00007/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00007/full

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