Dl-NBP (Dl-3-N-Butylphthalide) Treatment Promotes Neurological Functional Recovery Accompanied by the Upregulation of White Matter Integrity and HIF-1α/VEGF/Notch/Dll4 Expression

Dl-NBP (Dl-3-N-Butylphthalide) Treatment Promotes Neurological Functional Recovery Accompanied by the Upregulation of White Matter Integrity and HIF-1α/VEGF/Notch/Dll4 Expression

Dl-3-n-butylphthalide (dl-NBP) was approved by the FDA of China for the treatment of acute ischemic stroke. Dl-NBP has been shown to promote neurological functional recovery and enhance white matter integrity using an endothelin-1-induced focal permanent cerebral ischemia model, which could mimic th...

Full description

Bibliographic Details
Main Authors: Yanping Wang, Yufei Shen, Ziyun Liu, Jingxia Gu, Congying Xu, Shuxia Qian, Xiaoling Zhang, Beiqun Zhou, Yuhua Jin, Yanyun Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Pharmacology
Subjects:
dl-NBP
neurological functional recovery
white matter
HIF-1α-VEGF-Notch-Dll4
mice
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01595/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.01595/full

Similar Items