Cyclosporine Biosynthesis in <italic toggle="yes">Tolypocladium inflatum</italic> Benefits Fungal Adaptation to the Environment

Cyclosporine Biosynthesis in <italic toggle="yes">Tolypocladium inflatum</italic> Benefits Fungal Adaptation to the Environment

ABSTRACT The cycloundecapeptide cyclosporin A (CsA) was first isolated from the insect-pathogenic fungus Tolypocladium inflatum for its antifungal activity and later developed as an immunosuppressant drug. However, the full biosynthetic mechanism of CsA remains unknown and has puzzled researchers fo...

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Bibliographic Details
Main Authors: Xiuqing Yang, Peng Feng, Ying Yin, Kathryn Bushley, Joseph W. Spatafora, Chengshu Wang
Format: Article
Language:English
Published: American Society for Microbiology 2018-11-01
Series:mBio
Subjects:
cyclosporine
Tolypocladium inflatum
antifungal activity
biosynthetic pathway
virulence
Online Access:https://journals.asm.org/doi/10.1128/mBio.01211-18

Internet

https://journals.asm.org/doi/10.1128/mBio.01211-18

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