Design, Syntheses, and Bioevaluations of Some Novel <i>N</i><sup>2</sup>-Acryloylbenzohydrazides as Chemostimulants and Cytotoxic Agents

Design, Syntheses, and Bioevaluations of Some Novel <i>N</i><sup>2</sup>-Acryloylbenzohydrazides as Chemostimulants and Cytotoxic Agents

A series of novel <i>N</i><sup>2</sup>-acryloylhydrazides <b>1a–m</b> and a related series of compounds <b>6a–c</b> were prepared as potential chemostimulants. In general, these compounds are cytotoxic to human HCT 116 colon cancer cells, as well as hu...

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Bibliographic Details
Main Authors: Kinjal Lakhani, Edgar A. Borrego, Karla G. Cano, Jonathan R. Dimmock, Renato J. Aguilera, Swagatika Das, Praveen K. Roayapalley, Rajendra K. Sharma, Umashankar Das
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Medicines
Subjects:
acryloylhydrazides
cytotoxins
chemosensitization
antineoplastic agents
mitochondrial membrane potential
reactive oxygen species
Online Access:https://www.mdpi.com/2305-6320/8/6/27

Internet

https://www.mdpi.com/2305-6320/8/6/27

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