Oleanolic Acid Enhances Mesenchymal Stromal Cell Osteogenic Potential by Inhibition of Notch Signaling

Oleanolic Acid Enhances Mesenchymal Stromal Cell Osteogenic Potential by Inhibition of Notch Signaling

Abstract Oleanolic acid (OA), a pentacyclic triterpenoid, has been shown to modulate multiple signaling pathways in a variety of cell linages. But the mechanisms underlying OA-mediated mesenchymal stromal cell (MSC) osteogenic differentiation are not known. In this study, we examined effects of OA o...

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Bibliographic Details
Main Authors: Bing Shu, Yongjian Zhao, Yongjun Wang, Guangxi Wang, Xifu Shang, Michael Britt, Margaret Olmedo, Marjorie Chelly, Massimo Max Morandi, Shane Barton, Yufeng Dong
Format: Article
Language:English
Published: Nature Portfolio 2017-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-07633-7

Internet

https://doi.org/10.1038/s41598-017-07633-7

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