Expression of the genetic suppressor element 24.2 (GSE24.2) decreases DNA damage and oxidative stress in X-linked dyskeratosis congenita cells.

Expression of the genetic suppressor element 24.2 (GSE24.2) decreases DNA damage and oxidative stress in X-linked dyskeratosis congenita cells.

The predominant X-linked form of Dyskeratosis congenita results from mutations in DKC1, which encodes dyskerin, a protein required for ribosomal RNA modification that is also a component of the telomerase complex. We have previously found that expression of an internal fragment of dyskerin (GSE24.2)...

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Main Authors: Cristina Manguan-Garcia, Laura Pintado-Berninches, Jaime Carrillo, Rosario Machado-Pinilla, Leandro Sastre, Carme Pérez-Quilis, Isabel Esmoris, Amparo Gimeno, Jose Luis García-Giménez, Federico V Pallardó, Rosario Perona
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4079255?pdf=render

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http://europepmc.org/articles/PMC4079255?pdf=render

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