Sphingosine 1-Phosphate Receptor 5 (S1P5) Deficiency Promotes Proliferation and Immortalization of Mouse Embryonic Fibroblasts

Sphingosine 1-Phosphate Receptor 5 (S1P5) Deficiency Promotes Proliferation and Immortalization of Mouse Embryonic Fibroblasts

Sphingosine 1-phosphate (S1P), a bioactive lipid, interacts with five widely expressed G protein-coupled receptors (S1P1-5), regulating a variety of downstream signaling pathways with overlapping but also opposing functions. To date, data regarding the role of S1P5 in cell proliferation are ambiguou...

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Bibliographic Details
Main Authors: Franck Talmont, Elodie Mitri, Christine Dozier, Arnaud Besson, Olivier Cuvillier, Anastassia Hatzoglou
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Cancers
Subjects:
sphingosine-1phosphate
S1P5
MEF immortalization
cell proliferation
cell spreading
cell migration
Online Access:https://www.mdpi.com/2072-6694/14/7/1661

Internet

https://www.mdpi.com/2072-6694/14/7/1661

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