Metformin Inhibits Migration and Invasion by Suppressing ROS Production and COX2 Expression in MDA-MB-231 Breast Cancer Cells

Metformin Inhibits Migration and Invasion by Suppressing ROS Production and COX2 Expression in MDA-MB-231 Breast Cancer Cells

Background: Several mechanisms of action have been proposed to explain the apparent antineoplastic functions of metformin, many of which are observed at high concentrations that may not be reflective of achievable tissue concentrations. We propose that metformin at low concentrations functions to in...

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Bibliographic Details
Main Authors: Chandler Schexnayder, Kiera Broussard, Demitrius Onuaguluchi, Anthony Poché, Moamen Ismail, LeFontae McAtee, Shawn Llopis, Amber Keizerweerd, Harris McFerrin, Christopher Williams
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:International Journal of Molecular Sciences
Subjects:
metformin
ICAM1
metastasis
reactive oxygen species
COX2
Online Access:https://www.mdpi.com/1422-0067/19/11/3692

Internet

https://www.mdpi.com/1422-0067/19/11/3692

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