Deficiency of gluconeogenic enzyme PCK1 promotes metabolic-associated fatty liver disease through PI3K/AKT/PDGF axis activation in male mice

Deficiency of gluconeogenic enzyme PCK1 promotes metabolic-associated fatty liver disease through PI3K/AKT/PDGF axis activation in male mice

Phosphoenolpyruvate carboxykinase 1 (Pck1) is an enzyme involved in glucose production that also regulates lipogenesis and has been linked to liver steatosis. Here the authors report that deficiency of Pck1 in the liver leads to nonalcoholic fatty liver disease via activation of the RhoA/PI3K/AKT pa...

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Detalles Bibliográficos
Autores principales: Qian Ye, Yi Liu, Guiji Zhang, Haijun Deng, Xiaojun Wang, Lin Tuo, Chang Chen, Xuanming Pan, Kang Wu, Jiangao Fan, Qin Pan, Kai Wang, Ailong Huang, Ni Tang
Formato: Artículo
Lenguaje:English
Publicado: Nature Portfolio 2023-03-01
Colección:Nature Communications
Acceso en línea:https://doi.org/10.1038/s41467-023-37142-3

Internet

https://doi.org/10.1038/s41467-023-37142-3

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