Deficiency of gluconeogenic enzyme PCK1 promotes metabolic-associated fatty liver disease through PI3K/AKT/PDGF axis activation in male mice
Phosphoenolpyruvate carboxykinase 1 (Pck1) is an enzyme involved in glucose production that also regulates lipogenesis and has been linked to liver steatosis. Here the authors report that deficiency of Pck1 in the liver leads to nonalcoholic fatty liver disease via activation of the RhoA/PI3K/AKT pa...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-37142-3 |
| _version_ | 1827983349372682240 |
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| author | Qian Ye Yi Liu Guiji Zhang Haijun Deng Xiaojun Wang Lin Tuo Chang Chen Xuanming Pan Kang Wu Jiangao Fan Qin Pan Kai Wang Ailong Huang Ni Tang |
| author_facet | Qian Ye Yi Liu Guiji Zhang Haijun Deng Xiaojun Wang Lin Tuo Chang Chen Xuanming Pan Kang Wu Jiangao Fan Qin Pan Kai Wang Ailong Huang Ni Tang |
| author_sort | Qian Ye |
| collection | DOAJ |
| description | Phosphoenolpyruvate carboxykinase 1 (Pck1) is an enzyme involved in glucose production that also regulates lipogenesis and has been linked to liver steatosis. Here the authors report that deficiency of Pck1 in the liver leads to nonalcoholic fatty liver disease via activation of the RhoA/PI3K/AKT pathway in a study with male mice. |
| first_indexed | 2024-04-09T22:47:13Z |
| format | Article |
| id | doaj.art-a30c45d28e9344e29e4f12528c65a86c |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-09T22:47:13Z |
| publishDate | 2023-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-a30c45d28e9344e29e4f12528c65a86c2023-03-22T11:49:36ZengNature PortfolioNature Communications2041-17232023-03-0114111910.1038/s41467-023-37142-3Deficiency of gluconeogenic enzyme PCK1 promotes metabolic-associated fatty liver disease through PI3K/AKT/PDGF axis activation in male miceQian Ye0Yi Liu1Guiji Zhang2Haijun Deng3Xiaojun Wang4Lin Tuo5Chang Chen6Xuanming Pan7Kang Wu8Jiangao Fan9Qin Pan10Kai Wang11Ailong Huang12Ni Tang13Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical UniversityKey Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical UniversityKey Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical UniversityKey Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical UniversityInstitute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University (Army Medical University)Department of Infectious Disease, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People’s HospitalInstitute of Life Sciences, Chongqing Medical UniversityKey Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical UniversityKey Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical UniversityDepartment of Gastroenterology, Xin Hua Hospital, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Gastroenterology, Xin Hua Hospital, School of Medicine, Shanghai Jiao Tong UniversityKey Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical UniversityKey Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical UniversityKey Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical UniversityPhosphoenolpyruvate carboxykinase 1 (Pck1) is an enzyme involved in glucose production that also regulates lipogenesis and has been linked to liver steatosis. Here the authors report that deficiency of Pck1 in the liver leads to nonalcoholic fatty liver disease via activation of the RhoA/PI3K/AKT pathway in a study with male mice.https://doi.org/10.1038/s41467-023-37142-3 |
| spellingShingle | Qian Ye Yi Liu Guiji Zhang Haijun Deng Xiaojun Wang Lin Tuo Chang Chen Xuanming Pan Kang Wu Jiangao Fan Qin Pan Kai Wang Ailong Huang Ni Tang Deficiency of gluconeogenic enzyme PCK1 promotes metabolic-associated fatty liver disease through PI3K/AKT/PDGF axis activation in male mice Nature Communications |
| title | Deficiency of gluconeogenic enzyme PCK1 promotes metabolic-associated fatty liver disease through PI3K/AKT/PDGF axis activation in male mice |
| title_full | Deficiency of gluconeogenic enzyme PCK1 promotes metabolic-associated fatty liver disease through PI3K/AKT/PDGF axis activation in male mice |
| title_fullStr | Deficiency of gluconeogenic enzyme PCK1 promotes metabolic-associated fatty liver disease through PI3K/AKT/PDGF axis activation in male mice |
| title_full_unstemmed | Deficiency of gluconeogenic enzyme PCK1 promotes metabolic-associated fatty liver disease through PI3K/AKT/PDGF axis activation in male mice |
| title_short | Deficiency of gluconeogenic enzyme PCK1 promotes metabolic-associated fatty liver disease through PI3K/AKT/PDGF axis activation in male mice |
| title_sort | deficiency of gluconeogenic enzyme pck1 promotes metabolic associated fatty liver disease through pi3k akt pdgf axis activation in male mice |
| url | https://doi.org/10.1038/s41467-023-37142-3 |
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