Phage Display-Derived Compounds Displace hACE2 from Its Complex with SARS-CoV-2 Spike Protein

Phage Display-Derived Compounds Displace hACE2 from Its Complex with SARS-CoV-2 Spike Protein

Severe respiratory syndrome coronavirus-2 (SARS-CoV-2) is a highly contagious beta-class coronavirus. Although vaccinations have shown high efficacy, the emergence of novel variants of concern (VOCs) has already exhibited traits of immune evasion. Thus, the development of tailored antiviral medicati...

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Bibliographic Details
Main Authors: Marc Sevenich, Elena Thul, Nils-Alexander Lakomek, Thomas Klünemann, Maren Schubert, Federico Bertoglio, Joop van den Heuvel, Patrick Petzsch, Jeannine Mohrlüder, Dieter Willbold
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Biomedicines
Subjects:
SARS-CoV-2
coronavirus
spike protein
phage display
acute COVID-19 treatment
spike-hACE2 inhibitor
Online Access:https://www.mdpi.com/2227-9059/10/2/441

Internet

https://www.mdpi.com/2227-9059/10/2/441

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