Characterization of eicosanoid synthesis in a genetic ablation model of ceramide kinase[S]

Multiple reports have demonstrated a role for ceramide kinase (CERK) in the production of eicosanoids. To examine the effects of the genetic ablation of CERK on eicosanoid synthesis, primary mouse embryonic fibroblasts (MEFs) and macrophages were isolated from CERK−/− and CERK+/+ mice, and the ceram...

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Bibliographic Details
Main Authors: Jennifer A. Mietla, Dayanjan S. Wijesinghe, L. Alexis Hoeferlin, Michael D. Shultz, Ramesh Natarajan, Alpha A. Fowler, III, Charles E. Chalfant
Format: Article
Language:English
Published: Elsevier 2013-07-01
Series:Journal of Lipid Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520421327