Transcription initiation at a consensus bacterial promoter proceeds via a ‘bind-unwind-load-and-lock’ mechanism

Transcription initiation at a consensus bacterial promoter proceeds via a ‘bind-unwind-load-and-lock’ mechanism

Transcription initiation starts with unwinding of promoter DNA by RNA polymerase (RNAP) to form a catalytically competent RNAP-promoter complex (RPo). Despite extensive study, the mechanism of promoter unwinding has remained unclear, in part due to the transient nature of intermediates on path to RP...

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Bibliographic Details
Main Authors: Abhishek Mazumder, Richard H Ebright, Achillefs N Kapanidis
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-10-01
Series:eLife
Subjects:
RNA polymerase
smFRET
transcription initiation
Online Access:https://elifesciences.org/articles/70090

Internet

https://elifesciences.org/articles/70090

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