Amikacin potentiator activity of zinc complexed to a pyrithione derivative with enhanced solubility

Amikacin potentiator activity of zinc complexed to a pyrithione derivative with enhanced solubility

Abstract Resistance to amikacin in Gram-negatives is usually mediated by the 6'-N-acetyltransferase type Ib [AAC(6')-Ib], which catalyzes the transfer of an acetyl group from acetyl CoA to the 6' position of the antibiotic molecule. A path to continue the effective use of amikacin aga...

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Bibliographic Details
Main Authors: Jesus Magallon, Peter Vu, Craig Reeves, Stella Kwan, Kimberly Phan, Crista L. Oakley-Havens, Kenneth Rocha, Veronica Jimenez, María Soledad Ramirez, Marcelo E. Tolmasky
Format: Article
Language:English
Published: Nature Portfolio 2022-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-04724-4

Internet

https://doi.org/10.1038/s41598-021-04724-4

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