New variant and expression studies provide further insight into the genotype-phenotype correlation in YAP1-related developmental eye disorders

Abstract YAP1, which encodes the Yes-associated protein 1, is part of the Hippo pathway involved in development, growth, repair and homeostasis. Nonsense YAP1 mutations have been shown to co-segregate with autosomal dominantly inherited coloboma. Therefore, we screened YAP1 for variants in a cohort...

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Bibliographic Details
Main Authors: R. Holt, F. Ceroni, D. A. Bax, S. Broadgate, D. Gold Diaz, C. Santos, D. Gerrelli, N. K. Ragge
Format: Article
Language:English
Published: Nature Portfolio 2017-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-08397-w