Loss of Mpdz impairs ependymal cell integrity leading to perinatal‐onset hydrocephalus in mice

Loss of Mpdz impairs ependymal cell integrity leading to perinatal‐onset hydrocephalus in mice

Abstract Hydrocephalus is a common congenital anomaly. LCAM1 and MPDZ (MUPP1) are the only known human gene loci associated with non‐syndromic hydrocephalus. To investigate functions of the tight junction‐associated protein Mpdz, we generated mouse models. Global Mpdz gene deletion or conditional in...

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Bibliographic Details
Main Authors: Anja Feldner, M Gordian Adam, Fabian Tetzlaff, Iris Moll, Dorde Komljenovic, Felix Sahm, Tobias Bäuerle, Hiroshi Ishikawa, Horst Schroten, Thomas Korff, Ilse Hofmann, Hartwig Wolburg, Andreas vonDeimling, Andreas Fischer
Format: Article
Language:English
Published: Springer Nature 2017-07-01
Series:EMBO Molecular Medicine
Subjects:
aqueductal stenosis
cerebrospinal fluid
ependymal cells
hydrocephalus
tight junction
Online Access:https://doi.org/10.15252/emmm.201606430

Internet

https://doi.org/10.15252/emmm.201606430

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