FoxO3a Drives the Metabolic Reprogramming in Tamoxifen-Resistant Breast Cancer Cells Restoring Tamoxifen Sensitivity

FoxO3a Drives the Metabolic Reprogramming in Tamoxifen-Resistant Breast Cancer Cells Restoring Tamoxifen Sensitivity

Tamoxifen-resistant breast cancer cells (TamR-BCCs) are characterized by an enhanced metabolic phenotype compared to tamoxifen-sensitive cells. FoxO3a is an important modulator of cell metabolism, and its deregulation has been involved in the acquisition of tamoxifen resistance. Therefore, tetracycl...

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Bibliographic Details
Main Authors: Marco Fiorillo, Elena Ricci, Mariarosa Fava, Camilla Longobucco, Federica Sotgia, Pietro Rizza, Marilena Lanzino, Daniela Bonofiglio, Francesca Luisa Conforti, Stefania Catalano, Ines Barone, Catia Morelli, Saveria Aquila, Michael P. Lisanti, Diego Sisci
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Cells
Subjects:
FoxO3a
tamoxifen resistance
breast cancer
glycolysis
cancer metabolism
Online Access:https://www.mdpi.com/2073-4409/12/24/2777

Internet

https://www.mdpi.com/2073-4409/12/24/2777

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