Pro-Calcifying Role of Enzymatically Modified LDL (eLDL) in Aortic Valve Sclerosis via Induction of IL-6 and IL-33

Pro-Calcifying Role of Enzymatically Modified LDL (eLDL) in Aortic Valve Sclerosis via Induction of IL-6 and IL-33

One of the contributors to atherogenesis is enzymatically modified LDL (eLDL). eLDL was detected in all stages of aortic valve sclerosis and was demonstrated to trigger the activation of p38 mitogen-activated protein kinase (p38 MAPK), which has been identified as a pro-inflammatory protein in ather...

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Bibliographic Details
Main Authors: Annemarie Witz, Denise Effertz, Nora Goebel, Matthias Schwab, Ulrich F. W. Franke, Michael Torzewski
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Biomolecules
Subjects:
enzymatically modified LDL (eLDL)
calcification
aortic valve stenosis
VICs/myofibroblasts
p38 MAPK
IL-6
Online Access:https://www.mdpi.com/2218-273X/13/7/1091

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https://www.mdpi.com/2218-273X/13/7/1091

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