Purification, localization, and expression of human intestinal alkaline sphingomyelinase

Purification, localization, and expression of human intestinal alkaline sphingomyelinase

Sphingomyelin (SM) metabolism in the gut may have an impact on colon cancer development. In this study, we purified alkaline sphingomyelinase (alk-SMase) from human intestinal content, and studied its location in the mucosa, expression in colon cancer, and function on colon cancer cells. The enzyme...

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Bibliographic Details
Main Authors: Rui-Dong Duan, Yajun Cheng, Gert Hansen, Erik Hertervig, Jian-Jun Liu, Ingvar Syk, Hans Sjo¨stro¨m, Åke Nilsson
Format: Article
Language:English
Published: Elsevier 2003-06-01
Series:Journal of Lipid Research
Subjects:
colon cancer
apoptosis
proliferation
sphingolipid
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520311263

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http://www.sciencedirect.com/science/article/pii/S0022227520311263

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