CCR7 Is Recruited to the Immunological Synapse, Acts as Co-stimulatory Molecule and Drives LFA-1 Clustering for Efficient T Cell Adhesion Through ZAP70

CCR7 Is Recruited to the Immunological Synapse, Acts as Co-stimulatory Molecule and Drives LFA-1 Clustering for Efficient T Cell Adhesion Through ZAP70

The chemokine receptor CCR7 guides T cells and dendritic cells to and within lymph nodes to launch the onset of adaptive immunity. Here, we demonstrate that CCR7 in addition acts as a potent co-stimulatory molecule in T cell activation. We found that antigen recognition and engagement of the TCR res...

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Detaylı Bibliyografya
Asıl Yazarlar: Julia M. Laufer, Ilona Kindinger, Marc Artinger, Andreas Pauli, Daniel F. Legler
Materyal Türü: Makale
Dil:English
Baskı/Yayın Bilgisi: Frontiers Media S.A. 2019-01-01
Seri Bilgileri:Frontiers in Immunology
Konular:
CCR7
chemokine receptor
ZAP70
TCR
LFA-1
integrins
Online Erişim:https://www.frontiersin.org/article/10.3389/fimmu.2018.03115/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.03115/full

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