MeCP2 heterochromatin organization is modulated by arginine methylation and serine phosphorylation

MeCP2 heterochromatin organization is modulated by arginine methylation and serine phosphorylation

Rett syndrome is a human intellectual disability disorder that is associated with mutations in the X-linked MECP2 gene. The epigenetic reader MeCP2 binds to methylated cytosines on the DNA and regulates chromatin organization. We have shown previously that MECP2 Rett syndrome missense mutations are...

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Bibliographic Details
Main Authors: Annika Schmidt, Jana Frei, Ansgar Poetsch, Alexandra Chittka, Hui Zhang, Chris Aßmann, Anne Lehmkuhl, Uta-Maria Bauer, Ulrike A. Nuber, M. Cristina Cardoso
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
arginine (di)methylation
heterochromatin organization
MeCP2
protein arginine methyltransferases
Rett syndrome
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.941493/full

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https://www.frontiersin.org/articles/10.3389/fcell.2022.941493/full

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