Inhibition of merozoite invasion and transient de-sequestration by sevuparin in humans with Plasmodium falciparum malaria.

Inhibition of merozoite invasion and transient de-sequestration by sevuparin in humans with Plasmodium falciparum malaria.

SEVERE MALARIA:Even with the best available treatment, the mortality from severe Plasmodium falciparum malaria remains high. Typical features at death are high parasite loads and obstructed micro- vasculature. Infected erythrocytes (IE) containing mature parasites bind to the host receptor heparan s...

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Bibliographic Details
Main Authors: Anna M Leitgeb, Prakaykaew Charunwatthana, Ronnatrai Rueangveerayut, Chirapong Uthaisin, Kamolrat Silamut, Kesinee Chotivanich, Patima Sila, Kirsten Moll, Sue J Lee, Maria Lindgren, Erik Holmer, Anna Färnert, Mpungu S Kiwuwa, Jens Kristensen, Christina Herder, Joel Tarning, Mats Wahlgren, Arjen M Dondorp
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5731734?pdf=render

Internet

http://europepmc.org/articles/PMC5731734?pdf=render

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