Longitudinal clonal tracking in humanized mice reveals sustained polyclonal repopulation of gene-modified human-HSPC despite vector integration bias

Longitudinal clonal tracking in humanized mice reveals sustained polyclonal repopulation of gene-modified human-HSPC despite vector integration bias

Abstract Background Current understanding of hematopoiesis is largely derived from mouse models that are physiologically distant from humans. Humanized mice provide the most physiologically relevant small animal model to study human diseases, most notably preclinical gene therapy studies. However, t...

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Bibliographic Details
Main Authors: Gajendra W. Suryawanshi, Hubert Arokium, Sanggu Kim, Wannisa Khamaikawin, Samantha Lin, Saki Shimizu, Koollawat Chupradit, YooJin Lee, Yiming Xie, Xin Guan, Vasantika Suryawanshi, Angela P. Presson, Dong-Sung An, Irvin S. Y. Chen
Format: Article
Language:English
Published: BMC 2021-10-01
Series:Stem Cell Research & Therapy
Subjects:
HSPC
Gene therapy
Humanized mouse
LoVIS-Seq
VIS tracking
MDA
Online Access:https://doi.org/10.1186/s13287-021-02601-5

Internet

https://doi.org/10.1186/s13287-021-02601-5

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