Acute ischemic stroke triggers a cellular senescence-associated secretory phenotype

Abstract Senescent cells are capable of expressing a myriad of inflammatory cytokines and this pro-inflammatory phenomenon is known as senescence-associated secretory phenotype (SASP). The contribution of this phenomenon in brain ischemia was scarce. A mouse model of transient focal cerebral ischemi...

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Bibliographic Details
Main Authors: Coral Torres-Querol, Pascual Torres, Noemí Vidal, Manel Portero-Otín, Gloria Arque, Francisco Purroy
Format: Article
Language:English
Published: Nature Portfolio 2021-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-95344-5