Validation of the antibacterial effect of topically applied tranexamic acid using in vitro and in vivo models

Validation of the antibacterial effect of topically applied tranexamic acid using in vitro and in vivo models

BackgroundSeveral studies have shown that tranexamic acid (TXA), an antifibrinolytic, reduces postoperative infection rates. Recent in vitro research showed that TXA alone and in combination with vancomycin and gentamicin had a synergistic effect against some staphylococcal strains. In the present s...

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Bibliographic Details
Main Authors: Antonio Benjumea, Marta Díaz-Navarro, Ángela Sai Gago-Campos, Andrés Visedo, Rama Hafian, Emilia Cercenado, Mar Sánchez-Somolinos, Patricia Muñoz, Javier Vaquero, Francisco Chana, María Guembe
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-05-01
Series:Frontiers in Microbiology
Subjects:
tranexamic acid
vancomycin
gentamicin
synergistic effect
reduction
MIC
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2024.1367884/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2024.1367884/full

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